http://us.battle.net/d3/en/calculator/witch-doctor#bcYSif!bZW!abcYcY This is a build I'm experimenting with currently. Unlike most traditional Witch Doctor builds, you want your doctor in the middle of everything. Typical fight starts by summoning zombie dogs and having Posion Spiders/Plague Toads at the ready. Engage packs by throwing a few spiders out in the direction the zombie dogs move to, and begin to close range. Once up-close, begin tossing out plague toads as close to mobs as possible. The more toads the faster they die. As your dogs continue to move away, repeat with Poison Spiders and Plague Toads. This is fairly effective, even for what I consider a below-average damage dealing build. While using 0 debuffs your Witch Doctor is very vulnerable, a fully fleshed out build might include runes for increases to health (Leeching Beasts, For the Master) or perhaps switching a skill out for Hex/Grasp of the Dead. Primarily I did not include debuffs to give itemization most of the power here. With no debuffs, thorns damage becomes a viable option (provided that thorns is viable). Alternatively, stacking defensive stats (reduction, health) or damage could result in huge benefits as well.